Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides
نویسندگان
چکیده
منابع مشابه
Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides.
Epithelial carcinoma and leukemia cells express sialyl Lewis x oligosaccharides as tumor-associated carbohydrate antigens. To determine the role of sialyl Lewis x oligosaccharides in tumor dissemination, human melanoma MeWo cells, which do not express sialyl Lewis x, were transfected with alpha1,3-fucosyltransferase III (FTIII), and cell lines expressing different amounts of sialyl Lewis x were...
متن کاملC-Type Lectins and Sialyl Lewis X Oligosaccharides
Carbohydrates are major components of the outer surface of mammalian cells and these carbohydrates are very often characteristic of cell-types and developmental stages (Feizi, 1985; Hakomori, 1985). One of such cell type–specific carbohydrates is sialyl Lewis X, NeuNAc a 2 → 3Gal b 1 → 4(Fuc a 1 → 3)GlcNAc → R. Sialyl Lewis X and Lewis X, Gal b 1 → 4(Fuc a 1 → 3)GlcNAc, were originally discover...
متن کاملRecognition of asparagine-linked oligosaccharides on murine tumor cells by natural killer cells.
MDW4, a wheat germ agglutinin resistant mutant of the murine tumor line MDAY-D2, expresses abnormal asparagine-linked oligosaccharides, is less metastatic when injected intravenously, and is hypersensitive to natural killer (NK) lysis in vitro. To determine whether these phenotypes may be related, variants of the YAC-1 lymphoma and a YAC-1 X MDAY-D2 hybrid line were compared for sensitivity to ...
متن کاملA disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells.
Clustered presentation of sialyl Lewis X (sLe(X)) on tumor cell mucins is thought to facilitate metastasis through binding to selectin adhesion receptors expressed on platelets, leukocytes and endothelial cells. Thus, interfering with sLe(X) assembly might provide a chemotherapeutic method for treating metastatic disease. Prior studies have shown that peracetylated disaccharides can act in cell...
متن کاملContribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium.
The carbohydrate antigen, sialyl Lex, is known to be a ligand for the cell adhesion molecule called ELAM-1 (E-selectin, endothelial cell leukocyte adhesion molecule-1), which is present on cytokine-activated human endothelial cells. Recently, we reported that another carbohydrate antigen, sialyl Lea, can also serve as a ligand for ELAM-1 (A. Takada, K. Ohmori, N. Takahashi, K. Tsuyuoka, K. Yago...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.212456599